2021-04Thematic Section
The Horizontal-Ontological Nature of The Physical Culture of Cancers


Whereas classical Darwinian evolution is based on the model of vertical development, per species, and related sexual selection and natural mutations, along with environmental selective pressures, epi-genetics presents a supplemental view of horizontal development as DNA is both selectively transcribed and translated by mRNA and influenced by a process of horizontal gene transfer, including genetic melding of microbes, organelles, plants, animals and other types of hominoids. Thus, a philosophy of physical culture is offered in which cancers are conceived of as an extension of a horizontal physical culture in which organisms thrive via a cooperative and synergistic sense of community. However, they are also conceived of as an extreme which manifest a unique type of ontological multiplicity whereby they not only propagate para-sexually leading to vast genetic variations, but also manipulate and appropriate cells and systems of the host, constructing horizontally connected and lethal tumor sites. Is there any hope against such a formidable ontological structure? Cultivation of human metabolism via broad and healthy dietary patterns can support the horizontal microbiome, thus maintaining synchronized and unified horizontal relations between DNA, mRNA and long non-coded RNA functions.


vertical and horizontal evolution, metabolic microbiome, ontological metastatic multiplicity, synchronistic unity of actions

How to cite:

DeCarlo, John F. “The Horizontal-Ontological Nature of The Physical Culture of Cancers.” Eidos. A Journal for Philosophy of Culture 5, no. 4 (2021): 101-112. https://doi.org/10.14394/eidos.jpc.2021.0041.


John F. DeCarlo
Hofstra University
Hempstead, N.Y. 11549-1000, USA


Bach, Karsten, Sara Pensa, Marija Zarocsinceva, Katarzyna Kania, Julie Stockis, Silvain Pinaud, Kyren A. Lazarus, Mona Shehata, Bruno M Simões, Alice R. Greenhalgh, Sacha J. Howell, Robert B. Clarke, Carlos caldas, Timotheus Y. F. Halim, John C. Marioni, Walid T. Khaled. “Time-Resolved Single-Cell Analysis of Brca1 Associated Mammary Tumourgenesis Reveals Aberrant Differentiation of Luminal Progenitors.” Nature Communications 12, no. 1 (March 2021): 1502. https://doi.org/10.1038/s41467-021-21783-3.

Crisp, Alastair, Chiara Boschetti, Malcolm Perry, Alan Tunnacliffe, and Gos Micklem. “Expression of Multiple Horizontally Acquired Genes is a Hallmark of Both Vertebrate and Invertebrate Genomes.” Genome Biology 16, no. 50 (2015). https://doi.org/10.1186/s13059-015-0607-3.

DeCarlo, John F. “The Symbolic Link Between Bio Tech and Neuro Tech: An Imaginative Melding of Biological and Existential Homeostasis.” The Junkyard, December 9, 2020. https://junkyardofthemind.com/blog/2020/12/4/the-symbolic-link-between-bio-tech-amp-neuro-tech-an-imaginative-melding-of-biological-amp-existential-homeostasis.

Ganesh, Karuna, Harihar Basnet, Yasemin Kaygusuz, Ashely M. Laughney, Lan He, Roshan Sharma, Kevin P. O’Rourke, Vincent P. Reuter, Yun-Yan Huang, Mesruh Turkekul, Ekrem Emrah Er, Ignas Masilionis, Katia Manova-Todorova, Martin R Weiser, Leonard B. Saltz, Julio Garcia-Aguilar, Richard Koche, Scott W. Lowe, Dana Peer, Jinru Shia, and Joan Massagué. “L1CAM Defines the Regenerative Origin of Metastasis-Initiating Cells in Colorectal Cancer.” Nature Cancer 1, (2020): 28-45. https://doi.org/10.1038/s43018-019-0006-x.

Hammer, F. Michael. “Human Hybrids.” Scientific American 308, (May 2013): 66-71.

Harvard T.H. Chan School of Public Health. “Nutrition and Immunity.” Accessed January 2021. https://www.hsph.harvard.edu/nutritionsource/nutrition-and-immunity/.

Hormoz, Sahand, Debra Van Egeren, Javier Escabi, Maximilian Nguyen, Shichen Liu, Christopher R. Reilly, Sachin Patel, Baransel Kamaz, Maria Kalyva, Daniel J. DeAngelo, Ilene Galinsky, Martha Wadleigh, Eric S. Winer, Marlise R Luskin, Richard M. Stone, Jacqueline S. Garcia, Gabriela S. Hobbs, Fernando D. Camargo, Franziska Michor, Ann Mullally, and Isidro Cortes-Ciriano. “Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells In Myeloproliferative Neoplasms.” Cell Stem Cell 28, no. 3 (March 2021): 514-23. doi: 10.1016/j.stem.2021.02.001.

Jiang, Kevin. “Obesity and Cancer.” Harvard Medical School, News and Research, December 19, 2019. https://hms.harvard.edu/news/obesity-cancer.

Jiang, Kevin. “Original Error: When Does a Cancer First Arise?” Harvard Medical School, News and Research, March 4, 2021. https://hms.harvard.edu/news/original-error.

Luo, Ya, Jiqiao Yang, Jing Yu, Xiaowei Liu, Chune Yu, Jianping Hu, Hubing Shi, and Xuelei Ma. “Long Non-coding RNAs: Emerging Roles in the Immunosuppressive Tumor Microenvironment.” Frontiers in Oncology 10, no. 48 (January 2020). https://doi.org/10.3389/fonc.2020.00048.

Machado, Daniel, Oleksandr M. Maistrenko, Sergej Andrejev, Yongkyu Kim, Peer Bork, Kaustubh R. Patil, and Kiran R. Patil. “Polarization of microbial communities between competitive and cooperative metabolism.” Nature Ecology & Evolution 5, (2021): 195–203. https://doi.org/10.1038/s41559-020-01353-4.

Miller, Jen. “Gut Check.” Harvard Medical School, News and Research, May 18, 2021. https://hms.harvard.edu/news/gut-check.

Nurse, Paul. What Is Life? Five Great Ideas in Biology. W.W. Norton Company, New York: 2021.

Robison, E.K., Sergio Covarrubias, and Susan Carpenter. “The How and Why of lncRNA Function: An Innate Immune Perspective.”Biochim Biophys Acta Gene Regul Mech 1863, no. 4 (April 2020). https://doi.org/10.1016/j.bbagrm.2019.194419.

Sang, Lingjie, Huai-qiang Ju, Zuozhen Yang, Qiwei Ge, Zhen Zhang, Fangzhou Liu, Luojia Yang, Hangdi Gong, Chengyu Shi, Lei Qu, Hui Chen, Minjie Wu, Hao Chen, Ruihua Li, Qianqian Zhuang, Hailong Piao, Qingfeng Yan, Weishi Yu, Liangjing Wang, Jianzhong Shao, ian Liu, Wenqi Wang, Tianhua Zhou, and Aifu Lin. “Mitochondrial Long Non-Coding RNA GAS5 Tunes TCA Metabolism in Response to Nutrient Stress.” Nature Metabolism 3, (January 2021): 90-106. https://doi.org/10.1038/s42255-020-00325-z.

University of Cambridge. “Researchers Call for Greater Awareness of Unintended Consequences of CRISPR Gene Editing.” University of Cambridge Research News, April 12, 2021. https://www.cam.ac.uk/research/news/researchers-call-for-greater-awareness-of-unintended-consequences-of-crispr-gene-editing-0#:~:text=CRISPR%2DCas9%20genome%20editing%20can,human%20DNA%20in%20laboratory%20research.

Zimmer, Carl. She Has Her Mother’s Laugh: The Powers, Perversions, and Potential of Heredity.  Pan Macmillan-Dutton, 2018.

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